Candidates for Virulence Factors of Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
Iron – A Key Nexus in the Virulence of Aspergillus fumigatus
Iron is an essential but, in excess, toxic nutrient. Therefore, fungi evolved fine-tuned mechanisms for uptake and storage of iron, such as the production of siderophores (low-molecular mass iron-specific chelators). In Aspergillus fumigatus, iron starvation causes extensive transcriptional remodeling involving two central transcription factors, which are interconnected in a negative transcript...
متن کاملrtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus
Invasive aspergillosis by Aspergillus fumigatus is a leading cause of infection-related mortality in immune-compromised patients. In order to discover potential genetic targets to control A. fumigatus infections we characterized rtfA, a gene encoding a putative RNA polymerase II transcription elongation factor-like protein. Our recent work has shown that the rtfA ortholog in the model fungus As...
متن کاملGenes and molecules involved in Aspergillus fumigatus virulence.
Aspergillus fumigatus causes a wide range of diseases that include mycotoxicosis, allergic reactions and systemic diseases (invasive aspergillosis) with high mortality rates. Pathogenicity depends on immune status of patients and fungal strain. There is no unique essential virulence factor for development of this fungus in the patient and its virulence appears to be under polygenetic control. T...
متن کاملGenomics of Aspergillus fumigatus.
Aspergillus fumigatus is a filamentous fungal saprophyte that is ubiquitous in the environment. It is also a human pathogen and induces allergenic response, negatively impacting health care and associated costs significantly around the world. Much of the basic biology of this organism is only poorly understood, but the recent completion and publication of its genome sequence provides an excelle...
متن کاملCatalases of Aspergillus fumigatus.
Upon infection of a host, the pathogenic fungus Aspergillus fumigatus is attacked by the reactive oxygen species produced by phagocytic cells. Detoxification of hydrogen peroxide by catalases was proposed as a way to overcome this host response. A. fumigatus produces three active catalases; one is produced by conidia, and two are produced by mycelia. The mycelial catalase Cat1p was studied prev...
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ژورنال
عنوان ژورنال: Nippon Ishinkin Gakkai Zasshi
سال: 2008
ISSN: 0916-4804,1882-0476
DOI: 10.3314/jjmm.49.263